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KMID : 0603820120180030254
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 3 p.254 ~ p.259
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Differential Cytokine and Immunoglobulin Expressions in the Small Intestine of Echinostoma hortense Infected BALB/c Mice
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Jo Yoon-Kyung
Lee Dong-Sup
Kim Sung-In
Lee Ji-Sook
Oh Ji-Eun
Sung Ho-Joong
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Abstract
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Infections involving Echinostoma hortense (E. hortense) are considered to more severe than infections caused by other heterophyids. Although parasite expulsion by host immune responses attenuates the symptoms of infection, the detailed mechanisms of the host immune response need to be determined, especially in local immune responses involving cytokine and immunoglobulin expressions. We infected BALB/c mice with E. hortense and examined recovery rates together with expressions of multiple cytokines and immunoglobulins in the villi and crypts of the small intestine using immunohistochemistry. We observed a close correlation between worm expulsion rates and cytokine/immunoglobulin expressions in E. hortense infected mice. This study contributes to an understanding of the relationship between the immune response and parasite expulsion in hosts.
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KEYWORD
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Echinostoma hortense, Cytokines, Immunoglobulins, Small intestines, Immunohistochemistry
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